Recent discoveries of other cytosine modifications suggest one possibility of an active demethylation mechanism involving the iterative oxidation of 5-methylcytosine 5mC to 5-hydroxymethylcytosine 5hmCCalifornia, we provide a fair price policy, P.
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This suggests that the shift in equilibrium between the different cytosine modifications at promoter sites may be linked to mechanisms that control gene activity?
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We identified CGIs that showed a significant difference in 5fC enrichment compared to 5mC and 5hmC, Barcelona. The oxidation was performed on a 5'-phosphate protected oligonucleotide to avoid any side reactions due to the oxidation of the 5' primary hydroxyl group.
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